ANTsR: A package providing ANTs features in R as well as imaging-specific data representations, spatially regularized dimensionality reduction and segmentation tools. See also the Neuroconductor site: ANTsR interfaces state of the art image processing with R statistical methods. The project grew out of the need, at University of Pennsylvania, to develop large-scale analytics pipelines that track provenance from scanner to scientific study. ANTsR wraps an ANTs and ITK C++ core via Rcpp to access these frameworks from within R and support reproducible analyses. Specialized functionality in ANTsR includes image segmentation and registration along imaging specific variations of principal component and canonical correlation analysis.