RNAexinv: an extended inverse RNA folding from shape and physical attributes to sequences. RNAexinv is an interactive java application that performs RNA sequence design, constrained to yield a specific RNA shape and physical attributes. It is an extended inverse RNA folding program with the rationale behind that the generated sequences should not only fold into a desired structure, but they should also exhibit favorable attributes such as thermodynamic stability and mutational robustness. RNAexinv considers not only the secondary structure in order to design sequences, but also the mutational robustness and the minimum free energy. The sequences that are generated may not fully conform with the given RNA secondary structure, but they will strictly conform with the RNA shape of the given secondary structure and thereby take into consideration the recommended values of thermodynamic stability and mutational robustness that are provided.
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References in zbMATH (referenced in 2 articles )
Showing results 1 to 2 of 2.
- Haleš, Jozef; Héliou, Alice; Maňuch, Ján; Ponty, Yann; Stacho, Ladislav: Combinatorial RNA design: designability and structure-approximating algorithm in Watson-Crick and Nussinov-Jacobson energy models (2017)
- Picardi, Ernesto (ed.): RNA bioinformatics (2015)