• GCTA

  • Referenced in 16 articles [sw23135]
  • complex trait analysis. For most human complex diseases and traits, SNPs identified by genome-wide ... user-friendly software tool called genome-wide complex trait analysis (GCTA), which was developed based...
  • Rassoc

  • Referenced in 12 articles [sw25402]
  • testing association between genetic markers and a disease. The Cochran-Armitage trend test (CATT ... inheritance) is known. However, for most complex diseases, the underlying genetic models are unknown. Thus...
  • MDR

  • Referenced in 9 articles [sw22494]
  • environmental factors are associated with common, complex diseases has become a daunting task. This...
  • MaCH

  • Referenced in 7 articles [sw17274]
  • identify common alleles that contribute to complex disease susceptibility. Despite the large number of SNPs...
  • dmGWAS

  • Referenced in 3 articles [sw29291]
  • explore their combined effects on mediating complex diseases and traits. Integrative testing of GWAS association ... between genes underlying the pathogenesis of complex diseases. METHODS: Here, we present a dense module ... identify candidate subnetworks or genes for complex diseases by integrating the association signal from GWAS ... GWAS datasets for complex diseases, i.e. breast cancer and pancreatic cancer. For each disease...
  • SNPHarvester

  • Referenced in 5 articles [sw35289]
  • important in determining individual susceptibility to complex diseases. However, existing methods for SNP interaction discovery ... from high computation complexity or perform poorly when marginal effects of disease loci are weak...
  • Matrix eQTL

  • Referenced in 5 articles [sw20450]
  • search for genetic factors in complex diseases such as cancer, diabetes, and cystic fibrosis ... samples. This makes the analysis computationally complex as it involves independent testing for association...
  • GLOSSI

  • Referenced in 2 articles [sw35296]
  • association of genetic loci-sets with complex diseases. Results: In a simulation study, GLOSSI showed ... SNPs at multiple genetic loci with complex disease phenotypes. In contrast to methods based...
  • BhGLM

  • Referenced in 3 articles [sw10342]
  • rare and common variants, prediction of complex diseases and traits, gene-set and pathway analysis...
  • SIMLA

  • Referenced in 4 articles [sw00862]
  • linkage disequilibrium (LD) between marker and disease loci in general pedigrees. While the previous SIMLA ... linkage and association mapping of complex human diseases, it did not allow for the segregation ... incorporate environmental covariates possibly interacting with disease susceptibility genes. Here, we present an extension ... linkage and association analysis methods applied to complex human phenotypes. SIMLA can assist investigators...
  • epydemic

  • Referenced in 2 articles [sw31397]
  • extended to other, more complex, diseases. It also supports other network processes such as addition...
  • REVEAL

  • Referenced in 28 articles [sw36999]
  • covering whole genomes during development, health and disease, we seek computational methods to maximize functional ... possible, in principle, to completely infer a complex regulatory network architecture from input/output patterns...
  • GemTools

  • Referenced in 2 articles [sw33844]
  • uncover the genetic basis of complex disease, individuals are often measured at a large number...
  • LOT

  • Referenced in 2 articles [sw35330]
  • binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders...
  • CollHaps

  • Referenced in 2 articles [sw35234]
  • several genetic studies, e.g., mapping of complex disease genes, drug design, and evolutionary studies...
  • DNRLMF-MDA

  • Referenced in 1 article [sw23939]
  • disease mechanisms, developing drugs, and treating complex diseases. We all know that discovering the miRNA ... disease mechanisms, developing drugs, and treating complex diseases...
  • saa

  • Referenced in 1 article [sw20966]
  • prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes ... target disease of interest, especially if that disease is rare or poorly studied. Furthermore, individual ... integrative genetic risk prediction of complex diseases with binary phenotypes. It accommodates possible heterogeneity...
  • SNPmaxsel

  • Referenced in 3 articles [sw10515]
  • interactions. Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual...
  • DOSim

  • Referenced in 2 articles [sw18860]
  • DOSim package. We used the disease similarity application to demonstrate the relationship between 128 different ... obesity-related genes. The results revealed the complex pathogenesis of obesity. In addition, the gene ... complex pathogenesis of obesity risk phenotypes and the heterogeneity of obesity-related diseases. Conclusions: DOSim ... promote our understanding of the complex pathogenesis of diseases. DOSim is available on the Comprehensive...
  • DeepLGP

  • Referenced in 1 article [sw37448]
  • occurrence and development of complex diseases. Recent wet-lab experiments have shown that lncRNAs function...