iRSpot-EL: identify recombination spots with an ensemble learning approach. MOTIVATION: Coexisting in a DNA system, meiosis and recombination are two indispensible aspects for cell reproduction and growth. With the avalanche of genome sequences emerging in the post-genomic age, it is an urgent challenge to acquire the information of DNA recombination spots because it can timely provide very useful insights into the mechanism of meiotic recombination and the process of genome evolution. RESULTS: To address such a challenge, we have developed a predictor, called IRSPOT-EL: , by fusing different modes of pseudo K-tuple nucleotide composition and mode of dinucleotide-based auto-cross covariance into an ensemble classifier of clustering approach. Five-fold cross tests on a widely used benchmark dataset have indicated that the new predictor remarkably outperforms its existing counterparts. Particularly, far beyond their reach, the new predictor can be easily used to conduct the genome-wide analysis and the results obtained are quite consistent with the experimental map. AVAILABILITY AND IMPLEMENTATION: For the convenience of most experimental scientists, a user-friendly web-server for iRSpot-EL has been established at, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved

References in zbMATH (referenced in 29 articles )

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  1. Ahmad, Jamal; Hayat, Maqsood: MFSC: multi-voting based feature selection for classification of Golgi proteins by adopting the general form of Chou’s PseAAC components (2019)
  2. Ghosh, Avirup; Yan, Hong: Hydrogen bond analysis of the EGFR-ErbB3 heterodimer related to non-small cell lung cancer and drug resistance (2019)
  3. Hussain, Waqar; Khan, Yaser Daanial; Rasool, Nouman; Khan, Sher Afzal; Chou, Kuo-Chen: SPrenylC-PseAAC: a sequence-based model developed via Chou’s 5-steps rule and general PseAAC for identifying S-prenylation sites in proteins (2019)
  4. Jia, Jianhua; Li, Xiaoyan; Qiu, Wangren; Xiao, Xuan; Chou, Kuo-Chen: iPPI-PseAAC(CGR): identify protein-protein interactions by incorporating chaos game representation into PseAAC (2019)
  5. Khan, Yaser Daanial; Jamil, Mehreen; Hussain, Waqar; Rasool, Nouman; Khan, Sher Afzal; Chou, Kuo-Chen: pSSbond-PseAAC: prediction of disulfide bonding sites by integration of PseAAC and statistical moments (2019)
  6. Lu, Fuhua; Zhu, Maoshu; Lin, Ying; Zhong, Hongbin; Cai, Lei; He, Lin; Chou, Kuo-Chen: The preliminary efficacy evaluation of the CTLA-4-ig treatment against lupus nephritis through \textitin-silico analyses (2019)
  7. Pan, Yi; Wang, Shiyuan; Zhang, Qi; Lu, Qianzi; Su, Dongqing; Zuo, Yongchun; Yang, Lei: Analysis and prediction of animal toxins by various Chou’s pseudo components and reduced amino acid compositions (2019)
  8. Tahir, Muhammad; Tayara, Hilal; Chong, Kil To: iRNA-PseKNC(2methyl): identify RNA 2’-O-methylation sites by convolution neural network and Chou’s pseudo components (2019)
  9. Tian, Baoguang; Wu, Xue; Chen, Cheng; Qiu, Wenying; Ma, Qin; Yu, Bin: Predicting protein-protein interactions by fusing various Chou’s pseudo components and using wavelet denoising approach (2019)
  10. Wang, Lidong; Zhang, Ruijun; Mu, Yashuang: Fu-SulfPred: identification of protein S-sulfenylation sites by fusing forests via Chou’s general PseAAC (2019)
  11. Yan, Yuan Ting; Wu, Zeng Bao; Du, Xiu Quan; Chen, Jie; Zhao, Shu; Zhang, Yan Ping: A three-way decision ensemble method for imbalanced data oversampling (2019)
  12. Zhao, Xiaowei; Zhang, Ye; Ning, Qiao; Zhang, Hongrui; Ji, Jinchao; Yin, Minghao: Identifying N(^6)-methyladenosine sites using extreme gradient boosting system optimized by particle swarm optimizer (2019)
  13. Arif, Muhammad; Hayat, Maqsood; Jan, Zahoor: IMem-2LSAAC: a two-level model for discrimination of membrane proteins and their types by extending the notion of SAAC into Chou’s pseudo amino acid composition (2018)
  14. Cheng, Xiang; Xiao, Xuan; Chou, Kuo-Chen: pLoc_bal-mGneg: predict subcellular localization of Gram-negative bacterial proteins by quasi-balancing training dataset and general PseAAC (2018)
  15. Chiu, Jimmy Ka Ho; Dillon, Tharam S.; Chen, Yi-Ping Phoebe: Large-scale frequent stem pattern mining in RNA families (2018)
  16. Jia, Cangzhi; Yang, Qing; Zou, Quan: NucPosPred: predicting species-specific genomic nucleosome positioning via four different modes of general PseKNC (2018)
  17. Ju, Zhe; Wang, Shi-Yun: Prediction of S-sulfenylation sites using mRMR feature selection and fuzzy support vector machine algorithm (2018)
  18. Liang, Yunyun; Zhang, Shengli: Identify Gram-negative bacterial secreted protein types by incorporating different modes of PSSM into Chou’s general PseAAC via Kullback-Leibler divergence (2018)
  19. Mei, Juan; Fu, Yi; Zhao, Ji: Analysis and prediction of ion channel inhibitors by using feature selection and Chou’s general pseudo amino acid composition (2018)
  20. Qiu, Wenying; Li, Shan; Cui, Xiaowen; Yu, Zhaomin; Wang, Minghui; Du, Junwei; Peng, Yanjun; Yu, Bin: Predicting protein submitochondrial locations by incorporating the pseudo-position specific scoring matrix into the general Chou’s pseudo-amino acid composition (2018)

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